Essay topic 5. Neuromuscular junction as site of disease process. AND Formation of Nuromuscular junction.

Essay topic 5. 5. The neuromuscular occasion as a post of disease process Proteins involved in arrangement of the neuromuscular conjugation The neuromuscular junction is a specialize junction, where a give birth marrow forms its synaptic terminal with a muscle quality, one of umteen fibres that make up a whole muscle. The mature neuromuscular junction is composed of 3 types of kiosks - a motor kernel terminal, a muscle fibre and a Schwann cell c each over the junction. completely three of these cells argon highly differentiated and specialized for their functions (Kandel 2000, p. 1089). The events that go on during the formation of the neuromuscular junction have been extensively analyse and are the most comprehensively understood of any nerve-to-target cell contact. Prior to formation of the synapse all three components of the neuromuscular junction develop and acquire identities independently. The muscle cells are derived from the mesoderm and immigrate from the dermomyotomal portion of the somite. Motoneurons migrate from the ventricular zone of the neural fortress to a ventral-lateral location before axons grow out of the spinal anesthesia anesthesia anesthesia cord. Schwann cells are glial cells, which insulate the axons outside of the spinal cord, they are derived from neural crest cells and associate with axons from the somite forrader to the peripheral device target.

At the time of the first axons stretchability the developing muscle, the muscle fibres are myoblasts that have just coalesced to form multinucleated myotubes, there is no evidence to sug gest that motor neurons prefer certain situ! ate on the developing myotube or that there is a determine site for the formation of the synapse, on the contrary, synapse formation can occur on most, if not all of the myotube surface (Lichtman et al in Zigmond et al 2000, pp. 547-8). Acetylcholine receptors (AChR) are make up uniformly dispersed over the surface of the... If you want to get a full essay, ordinate it on our website: OrderCustomPaper.com

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